Compositions and methods for treating viral diseases

摘要

Substituted perhydro pyrrolopyridines and methods for their use in the treatment of HIV infections, AIDS, and AIDS-related diseases, and in the treatment of BVDV infections are described herein. Also, pharmaceutical compositions comprising the substituted perhydro pyrrolopyridines are useful for the treatment of HIV infections, AIDS, and AIDS-related diseases. The compositions include one or more carriers, diluents, or excipients, or a combination thereof.

主权项

1. A method for treating a host animal with HIV, the method comprising the step of administering to the host animal a pharmaceutical composition comprising a therapeutically effective amount of one or more compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 is arylcarbonyl, wherein aryl is monocyclic and is optionally substituted with halo or alkyl; R2 is aryl, wherein aryl is monocyclic and is optionally substituted with halo, alkyl, or alkoxyl, and wherein R2 is at C-3; R3 is arylmethyl, wherein aryl is monocyclic and is optionally substituted with halo, alkyl, or alkoxyl; and R4 is hydrogen; wherein the pharmaceutical composition optionally comprises one or more pharmaceutically acceptable carriers, dilutent, or excipients, or combinations thereof.