| 主权项 |
1. A method of closing an opening in a blood vessel, the method comprising:
inserting a closure device at least partially through the opening and into the blood vessel, the closure device including a delivery tube, an actuator, and a closure element, the closure element comprising a body having a proximal portion, a distal portion, and a waist portion, a distal end of the delivery tube being configured with a bias and applies a radial compressive force to the closure element; reconfiguring the distal portion of the closure element from a pre-deployed configuration to a deployed configuration, by pulling a distal end of the closure element in a proximal direction, while maintaining the proximal portion of the closure device in a pre-deployed configuration, wherein in the deployed configuration, one or more extensions of the distal portion protrude outward from the body beyond an outer edge of the opening in the blood vessel; engaging an inside portion of the blood vessel distally from the opening in the blood vessel with the distal portion of the closure device by moving the closure device in a proximal direction; following engaging the inside portion of the opening in the blood vessel, deploying the proximal portion of the closure element from the delivery tube; reconfiguring the proximal portion of the closure element from the pre-deployed configuration to a deployed configuration by collapsing a collapsible portion of the body in an outward direction, wherein in the deployed configuration, one or more extensions of the proximal portion protrude outward from the body to engage an outside portion of the blood vessel proximally from the opening in the blood vessel; and locking the proximal portion and the distal portion of the closure element in the deployed configuration by advancing a locking element formed on the actuator through a lumen of the proximal portion. |
