摘要 |
Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions. |
申请人 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III |
发明人 |
PASTOR FERNANDEZ, JOAQUIN;FERNANDEZ-CAPETILLO RUIZ, OSCAR;MARTINEZ GONZALEZ, SONIA;BLANCO APARICIO, CARMEN;RICO FERREIRA, MARIA DEL ROSARIO;TOLEDO LAZARO, LUIS IGNACIO;RODRIGUEZ ARISTEGUI, SONSOLES;MURGA COSTA, MATILDE;VARELA BUSTO, CARMEN;LOPEZ CONTRERAS, ANDRES JOAQUIN;RENNER, OLIVER;NIETO SOLER, MARIA;CEBRIAN MUNOZ, DAVID ALVARO |