DIRECT PRESSURE-MEDIATED INTRA-BONE DELIVERY SYSTEM FOR CELLULAR THERAPEUTICS

摘要

Disclosed are devices, apparatus, and methods for directly infusing one or more materials into a bone of a patient. More particularly, devices, apparatus and methods are provided for direct intra-bone infusion, wherein intra-bone pressure is continuously monitored and adjusted during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants.

主权项

1. An intra-bone infusion system for performing a bone marrow transplant comprising:
an infusion source; an intra-bone device having a proximal end for insertion into bone marrow, a distal end in connection with the infusion source, and a pressure sensor at the distal end for measuring intra-bone pressure; and a mechanism in communication with the pressure sensor and the infusion source, the mechanism configured and arranged to continuously monitor intra-bone pressure measurements by the pressure sensor, and to automatically adjust infusion of agents from the infusion source and into the intra-bone device so as to maintain intra-bone pressure at levels not exceeding systemic blood pressure.