| 发明名称 |
METHODS OF CONTROLLING TUMOR BIOENERGETICS NETWORKS |
| 摘要 |
Methods of stimulating anti-tumor activity in a subject with cancer are provided. The methods include administering to a subject in need thereof a low dose low dosage of a composition comprising a molecule that inhibits Hsp90 linked to a mitochondria-penetrating moiety; and administering to the subject an effective amount of an inhibitor of autophagy or glycolysis. |
| 申请公布号 |
US2016015725(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201314378691 |
申请日期 |
2013.02.14 |
| 申请人 |
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY |
发明人 |
Chae Young Chan;Altieri Dario C. |
| 分类号 |
A61K31/675;A61K31/7004;G01N33/574;A61K31/19;C12Q1/68;A61K45/06;A61K31/4706 |
主分类号 |
A61K31/675 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of stimulating anti-tumor activity in a subject with cancer comprising:
administering to a subject in need thereof a low dosage of a composition comprising a molecule that inhibits Hsp90 linked to a mitochondria-penetrating moiety; and administering to said subject an effective amount of an inhibitor of autophagy, wherein said low dosage is less than 5 μM. |
| 地址 |
Philadelphia PA US |
