IRINOTECAN HYDROCHLORIDE NANO LIPID BUNDLE PREPARATION AND PREPARATION METHOD THEREOF

摘要

Disclosed is an irinotecan hydrochloride nano lipid bundle preparation and a preparation method thereof, which comprises an entrapment material, irinotecan hydrochloride and an injectable aqueous solvent, wherein the entrapment material is selected from PLGA-PEG, PGA-PEG, PCL-PEG, PEG-NH2, PEG-COOH, DSPE-PEG, Solutol HS15 and a mixture of one or at least two types of phospholipids. The irinotecan hydrochloride nano preparation and irinotecan hydrochloride nano lipid bundle powder preparation are prepared from the irinotecan hydrochloride nano lipid bundle preparation.