| 发明名称 |
IMMUNOSTIMULATORY COMBINATIONS AND USE THEREOF |
| 摘要 |
Immunostimulatory combination are provided comprising: (i) a TLR agonist, (ii) a CD40 agonist, and (iii) an antigen, wherein said antigen consists of one or more antigenic peptides which range in size from 6-14 amino acids in length, wherein these moieties are each present in an amount that, in combination with the other, is effective to increase a subject's immune response to an antigen. The use of such short peptides unexpectedly enhances CD8+ T cell immunity. |
| 申请公布号 |
US2016015803(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201514802532 |
申请日期 |
2015.07.17 |
| 申请人 |
Kedl Ross |
发明人 |
Kedl Ross |
| 分类号 |
A61K39/21;A61K39/395;C12N7/00;C07K16/28 |
主分类号 |
A61K39/21 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An immunostimulatory combination comprising: (i) a TLR agonist, (ii) a CD40 agonist, and (iii) an antigen, wherein said antigen consists of one or more antigenic peptides which range in size from 6-14 amino acids in length, wherein these moieties are each present in an amount that, in combination with the other, is effective to increase a subject's immune response to an antigen. |
| 地址 |
Centennial CO US |
