发明名称 |
Anti-folate receptor alpha antibody glycoforms |
摘要 |
<p>The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti- FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.</p> |
申请公布号 |
AU2011317088(B2) |
申请公布日期 |
2016.01.21 |
申请号 |
AU20110317088 |
申请日期 |
2011.10.19 |
申请人 |
MORPHOTEK, INC. |
发明人 |
SASS, PHILIP M.;NICOLAIDES, NICHOLAS;GRASSO, LUIGI;ROUTHIER, ERIC;GU, WEI;YOUNG, JASON;YAO, JUN |
分类号 |
C07K16/30;A61K39/395;C12Q1/68;G01N27/00;G01R33/30 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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