| 主权项 |
1. A method of producing a testosterone formulation, comprising the steps of:
A. dissolving testosterone propionate, dibucaine HCl, and methylal in alcohol to form a first solution; B. heating polyethylene glycol 400 and polyethylene glycol 4000 to about 60 to 90° C. such that the polyethylene glycol 400 and the polyethylene glycol 4000 are dissolved and form a second solution, and stirring the second solution evenly; and C. cooling the second solution obtained from step B to 25 to 75° C. at a cooling rate lower than 0.06° C./sec, adding the cooled second solution into the first solution obtained from step A to form a third solution, stirring the third solution incessantly to facilitate emulsification, and, while the third solution keeps cooling down, stirring the third solution incessantly until the third solution is emulsified into an ointment. |
