| 发明名称 |
ANTI-B7-H4 ANTIBODIES AND IMMUNOCONJUGATES |
| 摘要 |
The disclosure provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same. |
| 申请公布号 |
US2016017040(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201414773334 |
申请日期 |
2014.03.13 |
| 申请人 |
GENENTECH, INC. |
发明人 |
Leong Steven R.;Polson Andrew;Polakis Paul;Wu Yan;Liang Wei-Ching;Firestein Ron |
| 分类号 |
C07K16/28;A61K47/48;G01N33/569;A61K39/395;A61K51/10;C07K16/30;A61K38/08 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that binds to B7-H4, wherein the antibody has at least one of the following characteristics:
(a) binds to an epitope within all or a portion of the B7-H4 Ig-V containing domain (amino acids 29-157 of SEQ ID NO: 73); or binds to an epitope within all or a portion of the B7-H4 Ig-C containing domain (amino acids 158-250 of SEQ ID NO: 73); or binds to an epitope within all or a portion of the B7-H4 Ig-V and Ig-C domains (amino acids 29-250 of SEQ ID NO:73); or binds to an epitope within all or a portion of SEQ ID NO: 74 (mature human B7-H4); or binds to an epitope within all or a portion of SEQ ID NO: 73 (precursor human B7-H4), and (b) binds to B7-H4 with an affinity of ≦50 nM. |
| 地址 |
South San Francisco CA US |
