| 发明名称 |
THROMBOXANE RECEPTOR ANTAGONISTS |
| 摘要 |
The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype. |
| 申请公布号 |
US2016016900(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201314391856 |
申请日期 |
2013.04.17 |
| 申请人 |
University College Dublin, National University of Ireland, Dublin |
发明人 |
Kinsella B. Therese;Guiry Patrick;Reid Helen;O'Connor Barry |
| 分类号 |
C07C311/58;C07D231/12;C07D261/08;C07D307/52;C07D213/53;C07D213/89;C07D295/192;C07D205/04;C07D305/08;C07D263/48;C07C311/59;C07D213/71;C07D277/34 |
主分类号 |
C07C311/58 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound represented by formula (I):wherein:
R1 is an alkyl group; and R2 is selected from the list consisting of a halogen, an alkyl group, and an aryl group, or a pharmaceutically acceptable salt thereof. |
| 地址 |
Dublin IE |
