GOLD COMPLEXES

摘要

Gold (I) hydroxide complexes of the form Z—Au—OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.

主权项

1. A method of catalyzing a chemical transformation, the method comprising:
contacting a gold (I) hydroxide complex of the form Z—Au—OH; ora digold (I) hydroxide complex according to general formula V:wherein the groups Z are two-electron donor ligands that are the same for each occurrence or that are different for each occurrence and A− is an anion, with a substrate.