Systems and Methods for Therapeutic Agent Delivery

摘要

According to some embodiments herein, systems for delivering therapeutic agents and/or methods of using such systems are provided. The systems can be configured to administer solution comprising therapeutic agent to a subject, and can further comprise an ultrasound applicator for applying ultrasound energy to the subject.

主权项

1. A system for ultrasonic delivery of a therapeutic agent, the system comprising:
an ultrasound transducer configured to deliver ultrasound energy toward an injected solution with the therapeutic agent dissolved therein to disperse the therapeutic agent into interstitial space of the target tissue; a sensor configured to monitor an acoustic response of the target tissue generated in response to ultrasound delivered by the ultrasound transducer; a controller coupled with the sensor and the ultrasound transducer, the controller configured to monitor the dispersal of the injected solution with the therapeutic agent dissolved therein based on the acoustic response of the target tissue monitored by the sensor and further configured to adjust the ultrasound delivery depending on the monitored acoustic response of the target tissue; wherein the sensor is further configured to measure a baseline acoustic response from the target tissue, and wherein the controller is configured to identify an end point for the ultrasound delivery by comparing the monitored acoustic response of the target tissue to the measured baseline acoustic response of the target tissue.