Genetically Detoxified Pertussis that Maintains Intrinsic Adjuvant Activity

摘要

The invention is directed to a method for the production of a pertussis vaccine and, in particular, a detoxified pertussis vaccine comprising detoxified pertussis toxin (PT), detoxified pertussis lipopolysaccharide (P-LPS), and detoxified pertussis adenylate cyclase toxin (P-ACT). The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a detoxified vaccine to patients.

主权项

1. A vaccine for the treatment or prevention of an infection in a mammal comprising:
a detoxified pertussis toxin protein; an enzyme treated LPS; and a detoxified adenylate cyclase protein.