Anti-Factor D Antibody Variants and Uses Thereof

摘要

The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

主权项

1. An anti-Factor D antibody variant with improved stability comprising substitution of at least one target aspartic acid (D or Asp) residue within a hypervariable region (HVR) of a reference anti-Factor D antibody, wherein the target Asp residue is identified as prone to isomerization and the substitution is Asp to Glutamic acid (E or Glu), and wherein the anti-Factor D antibody variant exhibits improved stability without significant loss of Factor D binding affinity when compared to the reference anti-Factor D antibody.