| 发明名称 |
ANTI-GPC3 ANTIBODIES AND IMMUNOCONJUGATES |
| 摘要 |
The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same. |
| 申请公布号 |
US2016017049(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201514718932 |
申请日期 |
2015.05.21 |
| 申请人 |
GENENTECH, INC. |
发明人 |
Polakis Paul;Chen Youjun |
| 分类号 |
C07K16/30;C07K16/28;A61K51/10;A61K47/48;A61K39/395 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that binds human GPC3, wherein the antibody binds to an epitope selected from:
a) an epitope within amino acids 25 to 137 of human GPC3; b) an epitope spanning the furin cleavage site at amino acids R358/S359 of human GPC3; c) an epitope within amino acids 420 to 470 of human GPC3; and d) an epitope within amino acids 470 to 509 of human GPC3. |
| 地址 |
South San Francisco CA US |
