| 发明名称 |
SELECTIVE TARGETING OF CANCER STEM CELLS |
| 摘要 |
Aspects of the invention relate to methods and related compositions for preferentially targeting cancer stem cells. In some embodiments, the methods utilize PKC-α/FRA1 pathway inhibitors to target carcinoma cells. Also provided are methods for identifying a candidate compound for selectively inhibiting growth of cancer stem cell, and methods for obtaining cells that have undergone an epithelial to mesenchymal transition. |
| 申请公布号 |
US2016017292(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201314441697 |
申请日期 |
2013.11.08 |
| 申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
TAM Wai Leong;WEINBERG Robert A. |
| 分类号 |
C12N5/09;A61K38/08;A61K31/404;A61K31/437;A61N5/10;A61K31/553;A61K31/704;A61K31/337;A61K31/403;A61K45/06;C12N15/113;A61K31/4045 |
主分类号 |
C12N5/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting growth of carcinoma cells, the method comprising:
determining that the carcinoma cells comprise cancer stem cells; and contacting the carcinoma cells with a PKC-α/FRA1 pathway inhibitor. |
| 地址 |
Cambridge MA US |
