发明名称 Treatment of Amyotrophic Lateral Sclerosis
摘要 The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
申请公布号 US2016016911(A1) 申请公布日期 2016.01.21
申请号 US201514867624 申请日期 2015.09.28
申请人 Silverman Richard B.;Zhang Yinan 发明人 Silverman Richard B.;Zhang Yinan
分类号 C07D231/18 主分类号 C07D231/18
代理机构 代理人
主权项 1. A compound selected from compounds of a formulawherein each of R1-R4 is independently selected from H, alkyl, cycloalkyl, alkylsulfonyl, alkylcarbonyl, aryl, arylalkyl, alkenylalkyl and alkynylalkyl moieties, and moieties where R3 and R1 together and R1 and R4 together form alkylene moieties; each of R′1-R′4 is independently selected from H, alkyl, amino, alkylamino, alkylsulfonyl, alkylcarbonyl, alkoxy, alkoxycarbonyl, cyano, and halo moieties and moieties where R′1 and R′2 together and R′3 and R′4 together form alkylene or alkenylene moieties; and each of m and n is an integer independently selected from 0-3, and salts, tautomers and combinations thereof.
地址 Winnetka IL US