发明名称 |
METHOD OF SYNTHESIS |
摘要 |
Described is a method of synthesizing 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0] octan-3-one by reacting 3-(5-ethoxyhept-1-yl) cyclopentene with dichloroketene. The resulting reaction products are reacted with acetic acid and zinc to produce 4-(5-ethoxy-hept-1-yl)bicyclo[3.2.0]heptan-6-one and 4-(5-ethoxyhept-1-yl)bicyclo[3.2.0]heptan-7-one, which are reacted with trimethylsulfonium iodide to produce 2-(5-ethoxyhept-1-yl)spiro[bicyclo[3.2.0]heptane-6,2′-oxirane] and 4-(5-ethoxyhept-1-yl)spiro-[bicyclo[3.2.0]heptane-6,2′-oxirane]. Lithium iodide is reacted with 2-(5-ethoxyhept-1-yl)spiro[bicyclo[3.2.0]heptane-6,2′-oxirane] and 4-(5-ethoxyhept-1-yl)spiro-[bicyclo-[3.2.0]heptane-6,2′-oxirane] to produce 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0]octan-3-one. A method of synthesizing 6-(5-methoxyhept-1-yl)bicyclo[3.3.0]octan-3-one is also described. |
申请公布号 |
US2016016874(A1) |
申请公布日期 |
2016.01.21 |
申请号 |
US201314773203 |
申请日期 |
2013.03.11 |
申请人 |
BCS BUSINESS CONSULTING SERVICES PTE LTD. |
发明人 |
VAN WITENBURG Jimmy;LA CROIS Rene |
分类号 |
C07C45/58;C07C45/65;C07C45/76 |
主分类号 |
C07C45/58 |
代理机构 |
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代理人 |
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主权项 |
1. A method of synthesizing a compound, the method comprising:
reacting 3-(5-ethoxyhept-1-yl) cyclopentene with dichloroketene to form a first mixture comprising 7,7-dichloro-4-(5-ethoxyhept-1-yl)bicyclo[3.2.0]heptan-6-one and 6,6-dichloro-4-(5-eth-oxyhept-1-yl)bicyclo[3.2.0]heptan-7-one; reacting the first mixture with acetic acid and zinc to form a second mixture comprising 4-(5-ethoxyhept-1-yl)bicyclo[3.2.0]heptan-6-one and 4-(5-ethoxyhept-1-yl) bicyclo[3.2.0]heptan-7-one; reacting the second mixture with trimethylsulfonium iodide to form a third mixture comprising 2-(5-ethoxyhept-1-yl)spiro[bicyclo[3.2.0]heptane-6,2′-oxirane] and 4-(5-ethoxyhept-1-yl)-spiro-[bicyclo-[3.2.0]heptane-6,2!-oxirane]; and reacting the third mixture with lithium iodide to form 6-(5-ethoxyhept-1-yl)bicyclo[3.3.0]octan-3-one. |
地址 |
Faber Hse SG |