| 发明名称 |
COMPOSITION FOR REGENERATING NORMAL TISSUE FROM FIBROTIC TISSUE |
| 摘要 |
The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition and the method employing a collagen-reducing substance. In accordance with the present invention, normal tissue can be therapeutically regenerated from fibrotic tissue. |
| 申请公布号 |
US2016015656(A2) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201313789032 |
申请日期 |
2013.03.07 |
| 申请人 |
Nitto Denko Corporation |
发明人 |
Niitsu Yoshiro;Yoneda Akihiro;Ishiwatari Hirotoshi;Payne Joseph E;Gaudette John A;Hou Zheng;Knopov Victor;Witte Richard P;Ahmadian Mohammad;Perelman Loren A;Tanaka Yasunobu;Akopian Violetta |
| 分类号 |
A61K31/07;A61K38/05;A61K38/48;A61K45/00 |
主分类号 |
A61K31/07 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising a collagen-reducing substance in an amount effective for regenerating normal tissue from fibrotic tissue, and a retinoid in an amount effective for targeting collagen-producing cells, wherein the retinoid is provided as a compound consisting of the structure (retinoid)m-linker-(retinoid)n, wherein m and n are independently 1, 2, or 3, and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule. |
| 地址 |
Osaka JP |
