| 摘要 |
<p>An in vitro method for the diagnosis of liver cirrhosis in a subject and /or for assessing whether a subject is at risk of developing liver cirrhosis, comprising the following steps: a)determining from a biological sample of said subject the abundance of each of the bacterial gene clusters of a set of bacterial gene clusters, wherein each of said clusters consisting of 50 non-redundant and covariant bacterial genes belonging to the same genome, defined in Tables 1, wherein said set of bacterial gene clusters comprise at least 2 bacterial gene clusters chosen in the group consisting in H_42, H_13, H_32, H_4, H_19, H_20, H_30, H_33, H_36, H_1, H_43, H_5, H_22, H_6, H_18, H_16, H_10, H_8, H_34, H_29, H_14, H_23, H_26, H_37, H_17, H_7, H_40, H_3, H_11, H_15, H_12, H_38, H_21, H_24, H_2, H_9, H_28, H_25, L_18, L_4, L_7, L_10, L_42, L_44, L_12, L_9, L_15, L_24, L_14, L_32, L_20, L_19, L_8, L_1, L_6, L_11, L_3, L_2, L_17, L_25, L_13, L_5, L_59, L_55, L_40, and L_39 from table 1. b)comparing the obtained abundances with at least one reference value, c)determining the diagnosis and/or risk of developing liver cirrhosis of said subject from said comparison.</p> |
