| 发明名称 |
MARKER OF BREAST TUMORS FROM THE LUMINAL-B SUBTYPE |
| 摘要 |
An in vitro method for diagnosing a breast cancer from the luminal-B subtype in a female, includes the steps of analyzing a biological sample from the female by (i) determining the copies number of the ZNF703 gene, and/or (ii) determining the expression of the ZNF703 gene, wherein an increased copies number and/or an over-expression of the ZNF703 gene is indicative of a luminal B tumor; to a kit for diagnosing a breast cancer from the luminal-B subtype in a female including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a method as defined previously, for determining the copies number of the ZNF703 gene, and/or determining the expression of the ZNF703 gene; and to the use of such a kit. |
| 申请公布号 |
US2016017439(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201514861880 |
申请日期 |
2015.09.22 |
| 申请人 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) ;Universite De La Mediterranee (Aix Marseille II) ;Institut Paoli-Calmettes |
发明人 |
BIRNBAUM Daniel;CHAFFANET Max;GINESTIER Christophe;ADELAIDE Jose;COULOMB Fabrice |
| 分类号 |
C12Q1/68;G01N33/574 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An in vitro method for diagnosing a breast cancer from the luminal-B subtype in a female, which comprises the steps of analyzing a biological sample from said female by:
i) determining the copies number of the Zinc Finger Protein 703 gene (ZNF703 gene), and/or ii) determining the expression of the ZNF703 gene wherein an increased copies number and/or an over-expression of the ZNF703 gene is indicative of a luminal B tumor. |
| 地址 |
Paris FR |
