发明名称 METHOD FOR PREPARING (2RS)-AMINO-(3S)-HYDROXY-BUTYRIC ACID AND ITS DERIVATIVES
摘要 The present invention relates to a method for easily preparing (2RS)-amino-(3S)-hydroxy-butyric acid, which is a chiral amino acid, in a high yield and a high purity using a chemical synthesis and enzymatic reduction reaction; an intermediate therefor; and a method for preparing the intermediate.
申请公布号 US2016017389(A1) 申请公布日期 2016.01.21
申请号 US201414770445 申请日期 2014.02.24
申请人 AMINOLOGICS Co., Ltd. 发明人 KANG Min Seok;LEE Hyun Il;UHM Ki Nam;KIM Jin Hyang
分类号 C12P13/04;C07C229/22 主分类号 C12P13/04
代理机构 代理人
主权项 1. A method for the preparation of (2RS)-amino-(3S)-hydroxy-butyric acid or its derivative of Formula 5, comprising obtaining the compound of Formula 9 from the compound of Formula 8 by an enzymatic reduction:wherein, R1 represents hydrogen, a linear or branched C1˜C4 alkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, a phenyl group, a benzyl group or a phenethyl group and wherein said alkyl can be unsubstituted or substituted with hydroxy or halogen, wherein R2 represents a linear or branched C1˜C4 alkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, a phenyl group, a benzyl group or a phenethyl group, wherein said alkyl can be unsubstituted or substituted with hydroxy or halogen and wherein R1 can be the same or different than R2.
地址 Seoul KR