发明名称 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENE
摘要 The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.
申请公布号 US2016017336(A1) 申请公布日期 2016.01.21
申请号 US201514724532 申请日期 2015.05.28
申请人 Alnylam Pharmaceuticals, Inc. 发明人 de Fougerolles Antonin;Novobrantseva Tatiana;Akinc Akin
分类号 C12N15/113 主分类号 C12N15/113
代理机构 代理人
主权项 1. A double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises at least two sequences that are substantially complementary to each other and wherein a sense strand of the dsRNA comprises a first sequence and an antisense strand of the dsRNA comprises a second sequence comprising a region that is substantially complementary to at least part of an mRNA encoding Factor VII, wherein each strand is at least 15 nucleotides in length and less than or equal to 30 nucleotides in length, and wherein said first sequence is selected from the group consisting of said sense strand sequences in Tables 1, 2, and 3, and wherein said second sequence is selected from the group consisting of said antisense strand sequences in Tables 1, 2, and 3.
地址 Cambridge MA US