发明名称 |
TARGETED THERAPY TO RESTORE RADIOACTIVE IODINE TRANSPORT IN THYROID CANCER |
摘要 |
The invention includes method, pharmaceutical compositions and uses thereof for treating patients with Papillary Thyroid Carcinoma (PTC) using a Platelet Derived Growth Factor Receptor Alpha (PDGFRA) inhibitor. The PDGFRA inhibitor is preferably an antibody specific to PDGFRA and causes an increase in the sensitivity level of PTC cells to radioiodine treatment. Moreover, the antibody can be used in combination with other PDGFRA inhibitors such as tyrosine kinase inhibitors and RNA interference molecules. |
申请公布号 |
WO2015166355(A3) |
申请公布日期 |
2016.01.21 |
申请号 |
WO2015IB01426 |
申请日期 |
2015.04.17 |
申请人 |
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA |
发明人 |
MCMULLEN, TODD;LOPEZ-CAMPISTROUS, ANA;WILLIAMS, DAVID |
分类号 |
A61K39/395;A61P35/00;C07K16/28;C12N15/113 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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