| 发明名称 |
Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same |
| 摘要 |
Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed. |
| 申请公布号 |
US2016016920(A1) |
申请公布日期 |
2016.01.21 |
| 申请号 |
US201414773022 |
申请日期 |
2014.03.14 |
| 申请人 |
THE UNIVERSITY OF TOLEDO |
发明人 |
Heck Bruce E.;Kim Dong Hyun;Erhardt Paul;Kress Brian |
| 分类号 |
C07D277/22 |
主分类号 |
C07D277/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inducing osteogenesis or chondrogenesis, comprising:
treating mammalian stem cells with an effective amount of one or more of: a peroxisome proliferator activated receptor (PPAR) agonist, whereby the mammalian stem cells differentiate into an osteocyte cell of osteoblast lineage, or into a chondrocyte cell of chondroblast lineage. |
| 地址 |
Toledo OH US |
