HETEROGENEOUS CATALYSTS FOR NMR/MRI ENHANCEMENT VIA SIGNAL AMPLIFICATION BY REVERSIBLE EXCHANGE (SABRE)

摘要

Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.

主权项

1. A heterogeneous catalyst of formula (I), wherein,is a solid support;
L is a bond or a linker; and Cat has formula: wherein R1 and R2 are each independently selected from aryl, heteroaryl, arylalkyl, heteroarylalkyl, wherein said aryl, heteroaryl, arylalkyl, and heteroarylalkyl are each independently unsubstituted or substituted with one or more suitable substituents; R3 and R4 are each independently selected from hydrogen and alkyl; R5 is halogen or pyridinyl, wherein said pyridinyl is unsubstituted or substituted with one or more suitable substituents; provided that one R1, R2, R3, R4, and R5 links to the solid support via L.