| 摘要 |
The faecal microbial communities and their functional composition are characterized by a whole gut microbiome-wild association study of stool samples from 98 liver cirrhosis patients and 83 healthy controls. Veillonella atypical ACS-134-V-Col7a is enriched in liver cirrhosis patients while Bacteroides uniformis ATCC 8492 and Clostridiales are enriched in controls. A biomarker for liver cirrhosis in human comprises Veillonella atypical ACS-134-V-Col7a and at least one bacterial strain over-represented in gut microbiota of healthy subject as compared to liver cirrhosis affected subjects, which comprises Bacteroides uniformis ATCC 8492 and Clostridiales. Veillonella atypical ACS-134-V-Col7a, Bacteroides uniformis ATCC 8492 and Clostridiales would be used for treating/preventing or diagnosing liver cirrhosis. |
