发明名称 |
TRANSITION METAL-BASED SELECTIVE FUNCTIONALIZATION OF CHALCOGENS IN BIOMOLECULES |
摘要 |
Disclosed are methods of selective cysteine and selenocysteine modification on peptide/protein molecules under physiologically relevant conditions. The methods feature several advantages over existing methods of peptide modification, such as specificity towards thiols and selenols over other nucleophiles (e.g., amines, hydroxyls), excellent functional group tolerance, and mild reaction conditions. |
申请公布号 |
CA2955232(A1) |
申请公布日期 |
2016.01.21 |
申请号 |
CA20152955232 |
申请日期 |
2015.07.15 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BUCHWALD, STEPHEN L.;PENTELUTE, BRADLEY L.;SPOKOYNY, ALEXANDER M.;VINOGRADOVA, EKATERINA V.;ZHANG, CHI |
分类号 |
C07K1/107;C07C321/24 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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