| 摘要 |
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I),;;or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ. |
| 主权项 |
1. A compound having the structure of formula (I):or a pharmaceutically acceptable salt thereof, wherein:
n is 0, 1, 2, or 3; each R1 is independently halo, cyano, unsubstituted or substituted alkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkoxy, hydroxy, unsubstituted or substituted cycloalkyl, SO2R1r, or C(O)NR1sR1t, wherein each R1r, R1s and R1t is independently hydrogen or unsubstituted or substituted alkyl; m is 0, 1, 2, or 3; each R2 is independently halo, cyano, unsubstituted or substituted alkyl, unsubstituted or substituted haloalkyl, or unsubstituted or substituted alkoxy; and R3 is hydrogen or unsubstituted or substituted alkyl. |
