发明名称 |
Drug Composition and Coating |
摘要 |
According to the invention there is provided inter alia a medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization. |
申请公布号 |
US2016015868(A1) |
申请公布日期 |
2016.01.21 |
申请号 |
US201514852708 |
申请日期 |
2015.09.14 |
申请人 |
W. L. Gore & Associates, Inc. |
发明人 |
Drumheller Paul D.;Cleek Robert L.;Johnson Todd J.;Holland Theresa A. |
分类号 |
A61L31/10;A61L31/16;A61K31/337 |
主分类号 |
A61L31/10 |
代理机构 |
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代理人 |
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主权项 |
1. A medical device for delivering a therapeutic agent to a tissue, the device having a solid surfactant-free particulate coating layer applied to a surface of the device, the coating layer comprising a therapeutic agent and at least one non-polymeric organic additive which is hydrolytically stable; wherein at least a proportion of the particulate coating layer comprising the therapeutic agent and the at least one organic additive melts as a single phase at a lower temperature than the melting point of the therapeutic agent and the at least one organic additive when in pure form; wherein the therapeutic agent is paclitaxel; and wherein the therapeutic agent, when formulated in the coating layer, is stable to sterilization. |
地址 |
Newark DE US |