ANTI-MESOTHELIN ANTIBODIES

摘要

An antibody that specifically binds to mesothelin has a heavy chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 1 and a light chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 3, a heavy chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 5 and a light chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 7, or a heavy chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 9 and a light chain recombinantly expressed from a nucleic acid sequence comprising SEQ ID NO: 11, or an antigen-binding fragment of the antibody. 4 1314 4 14 n Figure 2 MSAb-1 ADCC ACTIVITY 100 ---- - p=0.018 no Ab normal IgG MSAb-1