The present invention relates to polypeptide compounds that are modulators (e.g., agonists and antagonists) of the melanocortin-4 receptor (MC4R) and pharmaceutical compositions comprising same. The compounds described herein are polypeptide of the following structural Formula (I): or a pharmaceutically acceptable salt thereof. Values and preferred values of the variables in structural Formula (I) are described herein.
申请公布号
EP2970388(A1)
申请公布日期
2016.01.20
申请号
EP20140719988
申请日期
2014.03.14
申请人
RHYTHM PHARMACEUTICALS, INC.
发明人
SHARMA, SHUBH;VAN DER PLOEG, LEONARDUS, H.T.;HENDERSON, BART