| 发明名称 |
TRANSGENIC NON-HUMAN ORGANISMS WITH NON-FUNCTIONAL TSPO GENES |
| 摘要 |
The present invention relates to transgenic animal models. Specifically, the present invention relates to transgenic animal models for applications associated with TSPO-related normal physiology, diseases and disorders. The present invention features a transgenic nonhuman animal comprising cells with at least one copy of a non-functional, endogenous TSPO gene. Also disclosed are compounds for investigating or modulating TSPO-related functions. |
| 申请公布号 |
EP2971007(A1) |
申请公布日期 |
2016.01.20 |
| 申请号 |
EP20140764348 |
申请日期 |
2014.03.13 |
| 申请人 |
AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION;THE UNIVERSITY OF SYDNEY |
发明人 |
MIDDLETON, RYAN;BANATI, RICHARD;LIU, GUO JUN |
| 分类号 |
C12N15/85;A01K67/027;A61K31/437;A61P3/00;A61P25/00;A61P25/28;A61P35/00;C07D471/04;C07K14/705;C12N5/12;G01N33/50 |
主分类号 |
C12N15/85 |
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