| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method for inhibiting androgen receptor (AR) activity, which involves administering a therapeutically effective amount of a compound having a structure of formulainto an individual in need thereof, wherein X represents CHF, CHBr, CHI, CHOG, CHOGOG'; X' represents CHF, CHCl, CHBr, CHI, CHOJ''', CHOG, CHOGOG' or a fragment specified in the patent claim, X'' represents CHOG or CHOJ'''; each of J, J', J'' and J''' represents H; each of L, L', L'', Q, Q' and Q'' represents O; each of Z, Z' and Z'' represents CH; each of R, R, R', R', G, G' and G'' represents branched or unbranched unsubstituted C-Calkyl. The invention also refers to compounds of formula II, specific compounds presented in cl. 23 of the patent claim, pharmaceutical compositions, use and methods for inhibiting which involve administering the above compounds.EFFECT: diglycylyl ether derivatives inhibiting activity of androgen receptor and N-terminal domain of the androgen receptor.30 cl, 20 dwg, 5 tbl, 13 ex |
