发明名称 |
COMPOUNDS FOR IMPROVED STEM CELL DIFFERENTIATION INTO HEPATOCYTES |
摘要 |
The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications. |
申请公布号 |
EP2970178(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140709646 |
申请日期 |
2014.03.12 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
CHIAO, ERIC;HAMILTON, MATTHEW, MICHAEL;KAMEOKA, SEI;LEONARD, BRIAN;TRIYATNI, MIRIAM |
分类号 |
C07D401/04;A61K31/4439;A61P31/20 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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