发明名称 |
CONCENTRATED AQUEOUS AZALIDE FORMULATIONS |
摘要 |
Provided is concentrated aqueous azithromycin formulation from about from about 2%-20%, and a method of making a concentrated aqueous azithromycin formulation which includes preparing and sterilizing a first solution comprising a strong base to form a sterilized solution, dissolving the azithromycin in an aqueous solution comprising an acid consisting essentially of a strong acid, and adding the aqueous solution comprising the strong acid to the sterilized solution comprising the strong base. The strong acid has a pKa less than about −1.74 and the method is carried out without addition or use of a weak acid. |
申请公布号 |
EP2968383(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140767754 |
申请日期 |
2014.03.07 |
申请人 |
INSITE VISION INCORPORATED |
发明人 |
BOWMAN, LYLE, M.;HOU, SUI YUEN EDDIE;NGUYEN, TANG |
分类号 |
A61K31/7052;A61K9/08;A61K31/573;A61K47/02;A61K47/10;A61K47/32;A61K47/36;A61P27/02 |
主分类号 |
A61K31/7052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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