发明名称 |
COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS |
摘要 |
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance. |
申请公布号 |
EP2961431(A4) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140756899 |
申请日期 |
2014.02.07 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
STROBER, SAMUEL;LOWSKY, ROBERT |
分类号 |
A61K35/28;A61P37/06 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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