发明名称 |
HIGH THROUGHPUT MECHANICAL STRAIN GENERATING SYSTEM FOR CELL CULTURES AND APPLICATIONS THEREOF |
摘要 |
<p>The present application relates to an adaptable cell culture system that allows the application of mechanical strain to cells in culture through the displacement of a stretchable cell culture substrate. The system can apply dynamically heterogeneous strains to simulate the complex in vivo strain profiles on cultured cells, the strains including simulation of physiologic waveform such as a simulation of normal or diseased physiological biphasic stretch of the cardiac cycle, a simulation of normal or diseased physiological arterial waveform, or a cyclic mechanical strain. The system is modular and compatible with commercially available cell culture plate formats and robotic liquid handling devices. The system has a variety of applications including screening compounds for cardio toxicity or therapeutic activity, and identifying drug target, all using cell culture under the mechanical strain applied by the system.</p> |
申请公布号 |
EP2970850(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140716690 |
申请日期 |
2014.03.12 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BAKER, AARON;WONG, MITCHELL |
分类号 |
C12M1/32;C12M1/00;C12M1/12;C12M1/42;C12Q1/02 |
主分类号 |
C12M1/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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