发明名称 |
CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME |
摘要 |
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I). |
申请公布号 |
EP2968440(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140763699 |
申请日期 |
2014.03.14 |
申请人 |
CENTRE FOR DRUG RESEARCH AND DEVELOPMENT |
发明人 |
WINTERS, GEOFFREY C.;MANDEL, ALEXANDER LAURENCE;RICH, JAMES R.;HEDBERG, BRADLEY JOHN;HSIEH, TOM HAN HSIAO;BOURQUE, ELYSE MARIE JOSÉE;BABCOOK, JOHN |
分类号 |
C07K5/065;A61K31/18;A61K38/04;A61P35/00 |
主分类号 |
C07K5/065 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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