| 发明名称 |
HYBRID NECROPTOSIS INHIBITORS |
| 摘要 |
The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3. |
| 申请公布号 |
EP2968276(A1) |
申请公布日期 |
2016.01.20 |
| 申请号 |
EP20140763816 |
申请日期 |
2014.03.14 |
| 申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES;TUFTS UNIVERSITY;UNIVERSITY OF HOUSTON |
发明人 |
YUAN, JUNYING;DEGTEREV, ALEXEI;CUNY, GREGORY, D. |
| 分类号 |
C07D401/14;A61K31/4025;A61K31/4166;A61P9/00;A61P11/00;C07D471/04;C07D487/04 |
主分类号 |
C07D401/14 |
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