摘要 |
The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities. |
申请人 |
DART NEUROSCIENCE (CAYMAN) LTD |
发明人 |
BASINGER, JILLIAN;FREESTONE, GRAEME;GUPTA, VARSHA;KAPLAN, ALAN;MAK, CHI-CHING;PRATT, BENJAMIN;SANTORA, VINCENT;SENGUPTA, DIPANJAN;VALDEZ, LINO |