| 摘要 |
Disclosed is a glucose dehydrogenase (GDH) which has high thermal stability and high substrate specificity and can exhibit a high affinity for a substrate when nicotinamide adenine dinucleotide (NAD) is used as a coenzyme. A GDH having high thermal stability and strict substrate specificity can be obtained from hyperthermophilic archaea Thermoproteus sp. strain GDH1. Further, a modified GDH which can exhibit an improved affinity for glucose when NAD is used as a coenzyme can be successfully produced by substituting an amino acid residue located at a specific position in the aforementioned GDH by a different amino acid residue. |
