发明名称 |
Strain-promoted oxidation controlled cycloaddition with high reaction rate |
摘要 |
The invention provides a the use of a (hetero)cycloalkyne and an oxo-group containing (hetero)1,3-diene for coupling a first system (A) of interest to a second system (A') of interest, wherein a (hetero)cycloalkyne is created in one of the first system (A) of interest and the second system (A') of interest, and wherein an oxo-group containing (hetero)1,3-diene is created in the other system of interest, and allowing the (hetero)cycloalkyne and the oxo-group containing (hetero)1,3-diene to react to form an A-A' conjugate. |
申请公布号 |
EP2974744(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140177230 |
申请日期 |
2014.07.16 |
申请人 |
STICHTING KATHOLIEKE UNIVERSITEIT |
发明人 |
VAN DELFT, FLORIS LOUIS;FATUNSIN, OLUMIDE FOLUSO;BORRMANN, ANNIKA;VAN HEST, JAN CORNELIS MARIA;LÖWIK, DENNIS WILHELMUS PETRUS MARIA;JONKER, ANIKA MAARTJE |
分类号 |
A61K47/48;A61K47/32;C07D225/08 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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