| 摘要 |
FIELD: medicine.SUBSTANCE: angiogenesis factors in the form of plasmid vectors are introduced directly into gene tissues. Vascular growth factor genes are vectors containing HIF1a, HIF1b, VEGF165, VEGF225 genes in optimum stoichiometric ratio at 50-200 mcg of DNA per cmof the ischemic area at an area pitch of 2-10 mm. To provide more effective transfection, a vector solution is added with adjuvants.EFFECT: formation of adequate vessels and anastomoses with intact vasculature by the combined introduction of four angiogenesis factor genes that least to recovered perfusion and reduced ischemic events.2 cl, 4 ex, 2 tbl, 4 dwg |
