FORMULATION AND DELIVERY OF MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
摘要
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
申请公布号
EP2971010(A1)
申请公布日期
2016.01.20
申请号
EP20140724847
申请日期
2014.03.14
申请人
MODERNA THERAPEUTICS, INC.
发明人
HOGE, STEPHEN G.;ALMARSSON, ÖRN;HILE, DAVID D.;LAWLOR, CIARÁN;PODOBINSKI, JOHN;SABNIS, STACI;DE FOUGEROLLES, ANTONIN;RAMAKRISHNAN, DIVAKAR;WOOD, KRISTY M.