发明名称 |
PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF |
摘要 |
The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R 1 -R 7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof. |
申请公布号 |
EP2933250(A4) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20130864482 |
申请日期 |
2013.12.05 |
申请人 |
TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH |
发明人 |
ZHAO, GUILONG;WANG, YULI;LIU, BINGNI;XIE, YAFEI;LIU, YUQIANG;LIU, PENG;WU, JIANG;HOU, JIAJIA;WEI, WEI;DU, WEN;XU, WEIREN;TANG, LIDA;ZOU, MEIXIANG |
分类号 |
C07D309/10;A61K31/351;A61K31/381;A61K31/382;A61K31/7048;A61P3/10;C07D335/02;C07D407/12;C07D409/10;C07D493/08;C07D493/10;C07H1/00;C07H9/04;C07H19/01 |
主分类号 |
C07D309/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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