发明名称 |
COMPOSITIONS AND METHODS FOR IMMUNE TOLERANCE INDUCTION TO FACTOR VIII REPLACEMENT THERAPIES IN SUBJECTS WITH HEMOPHILIA A |
摘要 |
This disclosure relates to tolerance inducing peptide (TIP) derived from the amino acid reference locus (AARL) within a FVIII replacement product (FVIIIrp) based on the differences between the expression product of a subject's F8 gene (sFVIII) and the FVIIIrp to provide tolerance induction before, during, and/or after a FVIII replacement therapy in a subject suffering from Hemophila A. Methods of deriving, making, and using the TIP are also disclosed. In some embodiments, the TIP is associated with a nanoparticle, e.g., PLGA or PLGA-PEMA nanoparticle. |
申请公布号 |
EP2968499(A2) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140765535 |
申请日期 |
2014.03.17 |
申请人 |
HAPLOMICS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
HOWARD, TOMMY, E.;LA TERZA, VINCENT |
分类号 |
A61K39/00;A61K38/00;A61K38/04;C07K5/00;C07K7/00;C07K16/00;C07K17/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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