Non-antagonistic EGFR-binding molecules and immunoconjugates thereof

摘要

Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.

主权项

1. An antibody or antigen binding fragment thereof that specifically binds to human EGFR, wherein said antibody or antigen binding fragment thereof comprises:
a) a heavy chain variable region comprising the heavy chain CDR1 of SEQ ID NO:6, the heavy chain CDR2 of SEQ ID NO:7, 9, or 10, and the heavy chain CDR3 of SEQ ID NO:8; and b) a light chain variable region comprising the light chain CDR1 of SEQ ID NO:14, the light chain CDR2 of SEQ ID NO:15, and the light chain CDR3 of SEQ ID NO:16.