Radiolabeled amino acids for diagnostic imaging

摘要

This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogs thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

主权项

1. A compound of Formula III: wherein X is selected from:
a) CH2, andb) CH2—CH2, A is alkylene, Q is arylene or heteroarylene, L1 is selected from:
a) alkylene,b) alkylene-O*,c) alkylene-N*H,d) cycloalkylene-O*,e) monohydroxyalkylene,f) monohydroxyalkylene-O*,g) dihydroxyalkylene,h) dihydroxyalkylene-O*, andi) (CH2CH2O)n—CH2CH2—O* with n=1, 2 or 3,* indicates the position of the bond to Q, ora tautomer, a diastereomer, an enantiomer, a stereoisomer, a stereoisomeric mixture, or mixtures thereof.